Intranasal delivery comes up often in conversation and rarely with the context attached. Here we lay out the basics in order, then work through the practical considerations.
Updated 2026-01-20. Numbers and descriptions here follow the published literature rather than marketing material.
Published clinical work is concentrated in Russian-language journals and generally involves small samples without independent replication. Systematic reviews in English note the shortage of randomised, placebo-controlled trials and the difficulty of verifying methods from translated reports. Outcome measures vary between studies, which complicates pooling of results. Interest in the compound as a cognitive or anxiolytic agent therefore rests on a thinner evidence base than the volume of citations suggests. Replication in well-powered trials with preregistered endpoints would be needed before firm conclusions about efficacy can be drawn.
Proposed mechanisms centre on the GABAergic system. Animal and tissue studies report changes in GABA-A receptor expression and reduced activity of GABA transaminase, the enzyme that degrades GABA. Effects on monoamine turnover, including serotonin and dopamine pathways, are also described, and a separate line of work links the peptide to increased expression of brain-derived neurotrophic factor in hippocampal tissue. Most of these findings come from rodent models and cell preparations. How the individual observations combine into a single coherent mode of action is not settled.
Quality assessment of Selank samples typically combines purity determination with identity confirmation and counter-ion analysis. Purity is usually reported as a percentage by chromatographic area, with values above 95 percent often quoted for research-grade material. Water content and residual solvents are checked in lyophilized batches because they affect both stability and accurate mass determination. A reported purity figure does not by itself establish that a sample is the intended sequence, so orthogonal methods are needed to rule out sequence isomers or truncation products.
Characterization of Selank in laboratory settings relies on standard peptide analytical techniques. Reverse-phase high-performance liquid chromatography separates the peptide from related impurities and degradation products, while mass spectrometry confirms molecular identity through accurate mass measurement. Amino acid analysis and peptide sequencing verify the primary structure when reference material is unavailable. Because Selank is a short chain, fragmentation-based analysis produces a diagnostic ion pattern that supports confident identification.
Peptide stability depends strongly on temperature, moisture, and pH. Lyophilized Selank is generally most stable when stored cold and dry, with freezer temperatures commonly used for long-term storage. In solution, the compound is susceptible to hydrolysis and to microbial growth if it is not handled aseptically. The C-terminal proline-rich extension appears to slow enzymatic cleavage relative to tuftsin, though quantitative degradation rates vary with the matrix and the conditions tested. Published stability data specific to Selank remain sparse.
| Property | Value | Notes |
|---|---|---|
| Primary route studied | Intranasal | Also examined parenterally in animal work |
| Reported plasma half-life | Minutes to tens of minutes | Values vary widely between reports |
| Main model systems | Rodent behavioural and cell assays | Human trials are few and small |
| Principal proposed targets | GABA-A receptor, GABA transaminase | Monoamine and neurotrophic pathways also reported |
| Evidence grade | Preliminary | Limited independent replication |
The compound was designed at the Institute of Molecular Genetics of the Russian Academy of Sciences during the 1980s and 1990s. The stated design goal was to retain the immunomodulatory and central nervous system activity attributed to tuftsin while improving resistance to enzymatic breakdown. Adding a proline-rich tail to the short parent peptide was a deliberate strategy, because proline residues restrict the conformations available to many peptidases. The same laboratory produced Semax, an ACTH fragment analog, and both compounds were developed in parallel as short, enzymatically stabilized peptides intended for intranasal use.
Selank is not a naturally occurring peptide and has no known endogenous counterpart in human physiology. Russian-language sources frequently call it TP-7, while English-language sources use the name Selank almost exclusively. Database indexing is uneven, partly because early reports appeared in regional journals that are not widely cataloged. Some summaries describe the material as a tuftsin analog and others as a synthetic heptapeptide; the labels overlap rather than conflict. Citing the primary sequence resolves ambiguity more reliably than the research or trade name alone.
Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, written TKPRPGP in one-letter notation. Its structure consists of the immunomodulatory tetrapeptide tuftsin, Thr-Lys-Pro-Arg, extended at the carboxyl terminus by a Pro-Gly-Pro segment. The molecular formula is commonly given as C33H57N11O9, corresponding to a monoisotopic mass near 751.4 Da and an average molecular mass near 751.9 Da. All seven residues are proteinogenic amino acids, and the molecule carries no modified side chains or non-natural linkages.
Outside its country of origin the compound is generally handled as a research chemical rather than an approved medicine. No regulatory approval from the United States Food and Drug Administration or the European Medicines Agency has been granted for human use. Identity and purity are normally checked by reverse-phase high-performance liquid chromatography, with mass spectrometry used to confirm the molecular mass. Lyophilised material is stored cold and desiccated, and repeated freeze-thaw cycles are avoided.
Published work on this peptide almost always uses intranasal delivery, with drops or a spray applied to the nasal mucosa. Some animal experiments have used subcutaneous or intraperitoneal injection, and a smaller number have compared routes directly. Oral administration is not a focus of the literature, because short peptides of this size are broken down by digestive enzymes and cross intestinal barriers poorly. How much of an intranasal dose reaches the bloodstream intact in humans remains an open question.
Proposed mechanisms centre on modulation of the GABAergic system, with reports of altered expression of genes related to GABA-A receptor subunits and changed monoamine turnover. Some studies describe inhibition of enkephalinase, the enzyme that degrades endogenous enkephalins, which may prolong opioid peptide signalling. Effects on brain-derived neurotrophic factor and on cytokine expression have also been reported. These findings come largely from animal models and small human studies, and the precise primary target remains unresolved.
Published clinical evidence is limited. Most controlled trials were conducted in Russia, enrolled modest numbers of participants, and appeared in Russian-language journals, which restricts independent verification. Reported outcomes include lower anxiety scores, improved attention and memory measures, and changes in fatigue ratings. Reviews written in English note methodological limitations such as small samples and inconsistent endpoints. Whether the compound produces clinically meaningful benefit relative to established anxiolytics is therefore an open question rather than an established finding.
=== Secret peace discussions, opposition to troop withdrawals === In June 1969, the former Defense Secretary Clark Clifford published an article in Foreign Affairs calling for the withdraw of 100,000 U.S. troops from Vietnam by the end of 1969 and all by the end of 1970. Influenced by Laird, Nixon announced the immediate withdraw of 25,000 U.S. troops from Vietnam, saying: "I would hope that we could beat Mr. Clifford's timetable". Kissinger was opposed to the withdrawal, which he predicted would mean the immediate collapse of South Vietnam. On 4 August 1969, Kissinger met secretly with Xuân Thủy at the Paris apartment of Jean Sainteny to discuss peace. Sainteny was a former French colonial official sympathetic to Vietnamese nationalism who had offered to serve as an honest broker. Kissinger had been hoping to see Tho rather than Thuy. Kissinger repeated the American offer of "mutual withdrawal" of U.S. and North Vietnamese forces from South Vietnam, which Thủy rejected, while Thủy demanded a new government in Saigon, which Kissinger rejected. Kissinger had a low opinion of North Vietnam, saying "I can't believe that a fourth-rate power like North Vietnam doesn't have a breaking point". Kissinger was opposed to the strategy of Vietnamization, expressing some doubt about the ability of the ARVN (Army of the Republic of Vietnam-i.e. the South Vietnamese Army) to hold the field, causing much tension with Defense Secretary Laird who was deeply committed to Vietnamization. In September 1969, Kissinger, in a memo, advised Nixon against "de-escalation", saying that keeping U.S.
Treatments for the plastic repair of a broken nose are first mentioned in the Edwin Smith Papyrus, a transcription of text dated to the Old Kingdom from 3000 to 2500 BCE. The Ebers Papyrus (c. 1550 BC), an Ancient Egyptian medical papyrus, describes rhinoplasty as the plastic surgical operation for reconstructing a nose destroyed by rhinectomy. Such a mutilation was inflicted as a criminal, religious, political, and military punishment in that time and culture. Rhinoplasty techniques are described in the ancient Indian text Sushruta samhita by Sushruta, where a nose is reconstructed by using a flap of skin from the cheek. During the Roman Empire (27 BC – 476 AD) the encyclopaedist Aulus Cornelius Celsus (c. 25 BC – 50 AD) published the 8-tome De Medicina (On Medicine, c. 14 AD), which described plastic surgery techniques and procedures for the correction and the reconstruction of the nose and other body parts. At the Byzantine Roman court of the Emperor Julian the Apostate (331–363 AD), the royal physician Oribasius (c. 320–400 AD) published the 70-volume Synagogue Medicae (Medical Compilations, 4th century AD), which described facial-defect reconstructions that featured loose sutures that permitted a surgical wound to heal without distorting the facial flesh; how to clean the bone exposed in a wound; debridement, how to remove damaged tissue to forestall infection and so accelerate healing of the wound; and how to use autologous skin flaps to repair damaged cheeks, eyebrows, lips, and nose, to restore the patient's normal visage.
==== Vegetables ==== The guidelines for the safe storage of vegetables under dry conditions vary. This is because different vegetables have different characteristics; for example, tomatoes contain a lot of water, while root vegetables such as carrots and potatoes contain less. These factors, and many others, affect how long a vegetable can be kept in dry storage and the temperature required to preserve its usefulness. The following guideline shows the required dry storage conditions:
== Professor of Pathology and Head of Department Chronology == The Professor of Pathology is an established (statutory) chair at the University of Cambridge which was established in 1883. Traditionally, the Professor of Pathology was also the formal Head of department. However, in 2023 Professor Adrian Liston was elected to the Professor of Pathology while Professor Heike Laman was elected 10th Head of department and became the first woman to take on the role since the founding of the department in 1883.
There were 5,834 households, out of which 32.7% had children under the age of 18 living with them, 50.5% were married couples living together, 10.9% had a female householder with no husband present, and 35.2% were non-families. 29.9% of all households were made up of individuals, and 11.8% had someone living alone who was 65 years of age or older. The average household size was 2.40 and the average family size was 2.99. In the city, the population was spread out, with 26.7% under the age of 18, 9.0% from 18 to 24, 30.8% from 25 to 44, 19.9% from 45 to 64, and 13.7% who were 65 years of age or older. The median age was 34 years. For every 100 females, there were 91.2 males. For every 100 females age 18 and over, there were 85.8 males. The median income for a household in the city was $37,791, and the median income for a family was $47,769. Males had a median income of $35,614 versus $22,791 for females. The per capita income for the city was $18,245. About 4.4% of families and 7.1% of the population were below the poverty line, including 6.4% of those under age 18 and 10.6% of those age 65 or over.
Sources: en.wikipedia.org
Consumption in the 20th and 21st centuries has been abundantly pushed by automobile sector growth. The 1985–2003 oil glut even fueled the sales of low fuel economy vehicles in OECD countries. The 2008 economic crisis seems to have had some impact on the sales of such vehicles; still, in 2008 oil consumption showed a small increase. In 2016 Goldman Sachs predicted lower demand for oil due to emerging economies concerns, especially China. The BRICS (Brasil, Russia, India, China, South Africa) countries might also kick in, as China briefly had the largest automobile market in December 2009. In the long term, uncertainties linger; the OPEC believes that the OECD countries will push low consumption policies at some point in the future; when that happens, it will definitely curb oil sales, and both OPEC and the Energy Information Administration kept lowering their 2020 consumption estimates during the past five years. A detailed review of International Energy Agency oil projections have revealed that revisions of world oil production, price and investments have been motivated by a combination of demand and supply factors. All together, non-OPEC conventional projections have been fairly stable the last 15 years, while downward revisions were mainly allocated to OPEC. Upward revisions are primarily a result of US tight oil.
So, Stan Lee as a guy who is working for the Watchers was something that I thought was fun for the MCU." Feige added that Lee "clearly exists, you know, above and apart from the reality of all the films. So the notion that he could be sitting there on a cosmic pit stop during the jump gate sequence in Guardians...really says, so wait a minute, he's this same character who's popped up in all these films?" Following Lee's death, Marvel Studios chose not to create any new Lee cameos in future projects. NY1 news anchor Pat Kiernan has also appeared in multiple MCU films and television series as himself.
== Caesium-134 == Caesium-134 has a half-life of 2.0650 years. It is produced both directly (at a very small yield because 134Xe is stable) as a fission product and via neutron capture from nonradioactive 133Cs (neutron capture cross section 29 barns), which is a common fission product. It is not produced by nuclear weapons because 133Cs is created by beta decay of original fission products long after the nuclear explosion is over. The combined yield of 133Cs and 134Cs is given as 6.7896%. The proportion between the two will change with continued neutron irradiation. 134Cs also captures neutrons with a cross section of 140 barns, becoming long-lived radioactive 135Cs. Caesium-134 undergoes beta decay (β−), producing stable 134Ba after emitting on average 2.23 gamma ray photons (mean energy 0.698 MeV).
== History == AZD-2327 was first described by 2004 and was first described in the scientific literature in 2009. The development of AZD-2327 was discontinued in 2010. It reached phase 2 clinical trials for both depressive disorders and anxiety disorders prior to its discontinuation. No reason was given for the discontinuation of its development. However, the drug was found to be ineffective for major depressive disorder in a phase 2 clinical trial. AZD-2327 was developed by AstraZeneca.
Sources: en.wikipedia.org
Before Roemer's time in office, Louisiana had no limits on individual campaign contributions, which allowed donors to cut massive checks to campaigns without reporting the contributions. Roemer placed Kennedy in charge of his quest to toughen campaign finance laws, including placing a $5,000 cap on individual contributions to statewide candidates. In addition to ushering in the passage of campaign finance and product liability reforms for Roemer's administration, Kennedy led the effort to consolidate Louisiana's four boards of higher education into one. He said the policy would be "fundamental" to improving Louisiana universities' "quality and desegregation". That effort eventually came one vote short of passage. Roemer lost his reelection bid in 1991, but ran again in 1995 with Kennedy as his campaign manager. Roemer later endorsed Kennedy's bids for Senate. Kennedy remained close to Roemer until his death in 2021 and credited the former governor for getting him involved in public service.
== External operations == The Selous Scouts were involved in the Rhodesian military's attacks on insurgents and their bases in neighbouring countries, often known as external operations (or 'externals' for short). These operations became frequent from 1976. The unit's role in external operations included intelligence collection and directly attacking insurgents. In the intelligence gathering role, the Selous Scouts' Reconnaissance Troop conducted one or two man long-range reconnaissance patrols to locate or gather information on insurgent bases in Mozambique and Zambia. During direct attacks the Selous Scouts often impersonated soldiers of the country they were operating in. The Selous Scouts operated in eastern Botswana. This included fighting small actions against insurgents and a raid in which ZAPU leaders were captured in Francistown. The Selous Scouts also used pseudo tactics to collect intelligence in Francistown. Operation Long John was launched on 25 June 1976, against two guerilla bases located in Mozambique. This operation used 'flying column' tactics for the first time, which involved six vehicles manned by the Selous Scouts attacking the bases. Large quantities of munitions were destroyed, but few casualties were inflicted. On 9 August 1976, the Selous Scouts carried out Operation Eland, a raid on a ZANLA and FRELIMO controlled refugee camp at Nyadzonia in Mozambique. The Selous Scouts, who were mostly black and disguised in FRELIMO uniforms, included former Portuguese Army soldiers and a former ZANLA commander.
==== Washing machines ==== There are instances in which silver nanoparticles and colloidal silver are used in consumer goods. Samsung for example claimed that the use of silver nanoparticles in washing machines would help to sterilize clothes and water during the washing and rinsing functions, and allow clothes to be cleaned without the need for hot water. The nanoparticles in these appliances are synthesized using electrolysis. Through electrolysis, silver is extracted from metal plates and then turned into silver nanoparticles by a reduction agent. This method avoids the drying, cleaning, and re-dispersion processes, which are generally required with alternative colloidal synthesis methods. Importantly, the electrolysis strategy also decreases the production cost of Ag nanoparticles, making these washing machines more affordable to manufacture. Samsung has described the system:
=== First crewed spacecraft === Focused by the commitment to a Moon landing, in January 1962 the US announced Project Gemini, a two-person spacecraft that would support the later three-person Apollo by developing the key spaceflight technologies of space rendezvous and docking of two craft, flight durations of sufficient length to go to the Moon and back, and extra-vehicular activity to perform work outside the spacecraft. Meanwhile, Korolev had planned further long-term missions for the Vostok spacecraft, and had four Vostoks in various stages of fabrication in late 1963 at his OKB-1 facilities. The Americans' announced plans for Gemini represented major advances over the Mercury and Vostok capsules, and Korolev felt the need to try to beat the Americans to many of these innovations. He had already begun designing the Vostok's replacement, the next-generation Soyuz, a multi-cosmonaut spacecraft that had at least the same capabilities as the Gemini spacecraft. Soyuz would not be available for at least three years, and it could not be called upon to deal with this new American challenge in 1964 or 1965. Political pressure in early 1964 – which some sources claim was from Khrushchev while other sources claim was from other Communist Party officials – pushed him to modify his four remaining Vostoks to beat the Americans to new space firsts in the size of flight crews, and the duration of missions.
Four periods define Pakistani architecture: pre-Islamic, Islamic, colonial, and post-colonial. The onset of the Indus civilisation around the mid-3rd millennium BCE heralded an urban culture, evidenced by surviving large structures. Notable pre-Islamic settlements include Mohenjo-daro, Harappa, and Kot Diji. The fusion of Buddhism and Greek influences birthed a distinctive Greco-Buddhist style from the 1st century CE, exemplified by the renowned Gandhara style. Notable Buddhist architectural remnants include the Takht-i-Bahi monastery in Khyber Pakhtunkhwa. The advent of Islam in present-day Pakistan marked the cessation of Buddhist architecture, ushering in Islamic architecture. The notable Indo-Islamic structure, the tomb of Shah Rukn-i-Alam in Multan, remains significant. During the Mughal era, Persian-Islamic design merged with Hindustani art, seen in Lahore's architectural gems like the Badshahi Mosque and the Lahore Fort with the iconic Alamgiri Gate. Lahore also boasts the vibrant Wazir Khan Mosque, and the lush Shalimar Gardens. In the British colonial period, Indo-European buildings emerged, blending European and Indian-Islamic styles. Post-colonial identity shines through modern landmarks like the Faisal Mosque, Minar-e-Pakistan, and Mazar-e-Quaid. British architectural influence persists in structures across Lahore, Peshawar, and Karachi.
Sources: en.wikipedia.org
Reports describe modulation of GABA signalling, changes in monoamine turnover and effects on neurotrophic factor expression. These observations come mainly from animal and cell studies. A single unifying mechanism has not been demonstrated.
The peptide enters plasma rapidly and is broken down by ordinary proteases into amino acids and shorter fragments. Reported half-lives are short. Whether meaningful amounts of the intact molecule reach the brain is an open question.
Most clinical reports are small, published in Russian and not independently replicated. English-language reviews highlight the absence of large randomised trials. Conclusions about efficacy should be treated as provisional.
The most common approach combines reverse-phase liquid chromatography with mass spectrometry. Chromatography separates the components while mass spectrometry confirms the molecular mass. Peptide sequencing or tandem mass analysis can further verify the amino acid order.